Characterization of P2-purinoceptor mediated cyclic AMP formation in mouse C2C12 myotubes
نویسندگان
چکیده
منابع مشابه
P2 purinoceptor-mediated cardioprotection in ischemic-reperfused mouse heart.
P2 purinoceptor modulation of injury during ischemia-reperfusion was studied in murine hearts. Effects of P2 agonism or antagonism, and interstitial accumulation of P2 agonists (UTP, ATP, and ADP), were assessed in Langendorff perfused hearts during 20 min of ischemia and 45 min of reperfusion. In control hearts, ventricular pressure development recovered to 68 +/- 4 mm Hg (63 +/- 3% baseline),...
متن کاملAMP-activated protein kinase activation by -lipoic acid in C2C12 myotubes
[PDF] [Full Text] [Abstract] , May 15, 2008; 586 (10): 2651-2664. J. Physiol. Ford, P. W. Nathanielsz and M. Du M. J. Zhu, B. Han, J. Tong, C. Ma, J. M. Kimzey, K. R. Underwood, Y. Xiao, B. W. Hess, S. P. development impaired in fetuses of obese, over-nourished sheep AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle [PDF] [Full Text] [Abstract] , June 1...
متن کاملInterleukin-1 stimulates catabolism in C2C12 myotubes.
Interleukin-1 (IL-1) is an inflammatory cytokine that has been linked to muscle catabolism, a process regulated by muscle-specific E3 proteins of the ubiquitin-proteasome pathway. To address cellular mechanism, we tested the hypothesis that IL-1 induces myofibrillar protein loss by acting directly on muscle to increase expression of two critical E3 proteins, atrogin1/muscle atrophy F-box (MAFbx...
متن کاملMitochondrial calcium oscillations in C2C12 myotubes.
Mitochondrial Ca(2+) concentration ([Ca(2+)](m)) was monitored in C2C12 skeletal muscle cells stably expressing the Ca(2+)-sensitive photoprotein aequorin targeted to mitochondria. In myotubes, KCl-induced depolarization caused a peak of 3.03 +/- 0.14 micrometer [Ca(2+)](m) followed by an oscillatory second phase (5.1 +/- 0.1 per min). Chelation of extracellular Ca(2+) or blockade of the voltag...
متن کاملCyclic Amp and Folic Acid Mediated Cyclic Gmp Accumulation In
In a suitable environment spores of the Dictyostelia [ 1 ] germinate yielding small amoebae. Each amoebae feeds on bacteria and divides. Following consumption of the food supply amoebae aggregate forming a slug where cells differentiate into spores and stalk ceils. The orientation of cells towards a food source or an aggregation center is guided by gradients of concentration of chemotactic mole...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb13782.x